Abcam, ab164948, Recombinant Human CGB5 protein

Size: 10µg
Recombinant Human CGB5 protein is a Human Full Length protein, in the 1 to 165 aa range, expressed in Wheat germ, suitable for ELISA, WB.
Key facts
Expression system:Wheat germ,
Tags:GST tag N-Terminus,
Applications:ELISA, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Biologically active:No,
Accession:P0DN86,
Animal free:No,
Carrier free:No,
Species:Human,
Storage buffer:pH: 8Constituents: 0.79% Tris HCl, 0.31% Glutathione

Properties and Storage Information:
Shipped at conditions-Dry Ice, Appropriate short-term storage conditions--80°C, Appropriate long-term storage conditions--80°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
CGB5 also known as chorionic gonadotropin subunit beta 5 is a protein closely related to the hormonal function in mammals. It belongs to the beta subunit of the human chorionic gonadotropin (hCG) hormone. This protein has a molecular mass of approximately 22 kDa and is expressed mainly in the placenta. Its expression is highly regulated during pregnancy contributing to various reproductive processes.
Biological function summary
The chorionic gonadotropin subunit beta 5 plays a significant role in supporting the uterine environment. It is a critical part of the larger glycoprotein hormone complex which includes the alpha subunit. This complex interacts with luteinizing hormone/chorionic gonadotropin receptors (LHCGR) in the ovary facilitating the maintenance of the corpus luteum and promoting progesterone production. This biological activity is important for successful embryonic implantation and maintenance of early pregnancy.
Pathways
CGB5 is integral to the reproductive and hormonal regulatory pathways. It actively participates in the gonadotropin-releasing hormone pathway which influences other key hormones involved in reproductive functions. Within this pathway CGB5 interacts with luteinizing hormone (LH) as both play critical roles in fertility and menstrual regulation processes.
CGB5 shows associations with trophoblastic diseases such as choriocarcinoma and other gestational trophoblastic diseases. Abnormal expression or mutations in CGB5 can result in gestational trophoblastic neoplasms. Its disease association is often understood alongside other proteins like CGB7 which share similar functions in the beta subunit family. Understanding these connections helps in targeted interventions and therapeutic strategies to manage related reproductive health issues.