Abcam, ab165460, Recombinant Human APOBEC3D protein

Size: 10µg
Recombinant Human APOBEC3D protein is a Human Full Length protein, in the 1 to 386 aa range, expressed in Wheat germ, suitable for ELISA, WB.
Key facts
Expression system:Wheat germ,
Tags:GST tag N-Terminus,
Applications:WB, ELISASee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Biologically active:No,
Accession:Q96AK3,
Animal free:No,
Carrier free:No,
Species:Human,
Storage buffer:pH: 8Constituents: 0.79% Tris HCl, 0.31% Glutathione

Properties and Storage Information:
Shipped at conditions-Dry Ice, Appropriate short-term storage conditions--80°C, Appropriate long-term storage conditions--80°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
APOBEC3D also known as APOBEC-related cytidine deaminase plays a role in the editing of nucleic acids by deaminating cytosine to uracil in single-stranded DNA. This protein possesses a mass of approximately 46 kDa. APOBEC3D is expressed primarily in lymphoid tissues including the spleen and lymph nodes. It belongs to a larger group of APOBEC family proteins that extend their functions to various aspects of nucleic acid metabolism.
Biological function summary
The protein modifies DNA sequences and contributes to the innate immune response which acts as a defense against viral infections. APOBEC3D participates as a component of the host's antiviral machinery generating mutations in viral genomes that can inhibit virus replication. While it does not form a stable complex akin to some of its family members such as APOBEC3G its activity associates with the presence of the APOBEC3 protein family acting coordinately in host cellular processes.
Pathways
APOBEC3D integrates into the broader mechanism of intrinsic immunity specifically targeting viral genomes for mutation. The protein also intersects with pathways connected to nucleic acid processing. Related proteins in these immunity pathways include APOBEC3G and APOBEC3F which similarly act to induce hypermutation in retroviral and other viral agents offering a collective resistance against viral propagation.
APOBEC3D has links to certain autoimmune disorders and cancer. The activity of APOBEC3D like its relatives can contribute to genome hypermutation which plays a part in cancer development and progression. APOBEC3D in combination with other members like APOBEC3B contributes to mutational signatures found in various cancer types highlighting its potential role in tumorigenesis. Studies continue to investigate its impact on HIV-1 infection reinforcing its connection with the body's defense mechanisms and potential implications in disease resistance or susceptibility.