Abcam, ab165502, Recombinant Human LDLRAD3 protein

Size: 10µg
Recombinant Human LDLRAD3 protein is a Human Full Length protein, in the 1 to 345 aa range, expressed in Wheat germ, suitable for ELISA, WB.
Key facts
Expression system:Wheat germ,
Tags:GST tag N-Terminus,
Applications:ELISA, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Biologically active:No,
Accession:Q86YD5,
Animal free:No,
Carrier free:No,
Species:Human,
Storage buffer:pH: 8Constituents: 0.79% Tris HCl, 0.31% Glutathione

Properties and Storage Information:
Shipped at conditions-Dry Ice, Appropriate short-term storage conditions--80°C, Appropriate long-term storage conditions--80°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
LDLRAD3 also known as Low-Density Lipoprotein Receptor Class A Domain-Containing Protein 3 performs essential roles on a mechanical level. This protein has an approximate molecular mass of 90 kDa and is ubiquitously expressed on the cell surface of various tissues with high presence in the brain. Its structural domains facilitate interactions with extracellular molecules suggesting its involvement in transmembrane signaling. The understanding of LDLRAD3's roles benefits from studying its distribution in different cells and tissues.
Biological function summary
The LDLRAD3 protein interacts with cellular processes that manage cholesterol uptake and homeostasis. It does not function as a single unit but may integrate into larger protein complexes to enhance its efficiency. Researchers suggest that LDLRAD3’s function in lipid metabolism and transport is significant particularly in the central nervous system. The collaboration of LDLRAD3 with other receptor proteins assists in regulating these activities and maintaining cellular metabolism.
Pathways
The action of the protein interfaces with lipid metabolism and signal transduction pathways. LDLRAD3 plays a role in the low-density lipoprotein receptor pathway participating in lipid uptake and signaling tied to metabolic regulation. This protein engages with the LDL receptor family connecting with proteins like ApoE which have established roles in lipid transport and cardiovascular health. LDLRAD3’s integration into these pathways highlights its physiological relevance.
The involvement of LDLRAD3 links to neurological conditions and cardiovascular diseases. In Alzheimer's disease LDLRAD3 shows associations due to its interaction with ApoE an important protein involved in the disease's progression. Additionally this protein may play a part in hypercholesterolemia where LDLRAD3-mediated pathways affect cholesterol levels in the blood. These associations highlight the importance of LDLRAD3 as a research target for therapy development.