Abcam, ab165727, Recombinant Human FITM1 protein

Size: 10µg
Recombinant Human FITM1 protein is a Human Full Length protein, in the 1 to 292 aa range, expressed in Wheat germ, suitable for ELISA, WB.
Key facts
Expression system:Wheat germ,
Tags:GST tag N-Terminus,
Applications:WB, ELISASee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Biologically active:No,
Accession:A5D6W6,
Animal free:No,
Carrier free:No,
Species:Human,
Storage buffer:pH: 8Constituents: 0.79% Tris HCl, 0.31% Glutathione

Properties and Storage Information:
Shipped at conditions-Dry Ice, Appropriate short-term storage conditions--80°C, Appropriate long-term storage conditions--80°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
FITM1 also known as Fat Storage-Inducing Transmembrane Protein 1 functions as a lipid droplet protein involved in lipid storage. This protein identifies in mammals with a sequence mass around 29 kDa. It expresses heavily in adipose tissues and to a lesser extent in liver and muscle tissues. FITM1 plays an essential role in regulating lipid droplet formation within these tissues.
Biological function summary
FITM1 facilitates the storage of neutral lipids within cells contributing to overall lipid metabolism. It acts as part of a molecular complex that anchors triglycerides within lipid droplets enabling efficient lipid storage. Through this mechanism FITM1 participates in maintaining cellular lipid balance reflecting its significance in fat storage physiology.
Pathways
FITM1 integrates within metabolic pathways associated with lipid processing and energy homeostasis. Two important pathways include the lipid metabolic pathway and the insulin signaling pathway. FITM1 operates alongside proteins like FITM2 and perilipin where they coordinate to manage lipid droplet dynamics thereby influencing cellular energy metabolism.
FITM1 influences the development of metabolic syndromes such as obesity and non-alcoholic fatty liver disease (NAFLD). Dysregulation of FITM1 affects lipid storage capacity linking it to these conditions. FITM1 connects with proteins involved in these disorders including adiponectin and leptin which play significant roles in energy metabolism and homeostasis.