Abcam, ab166189, Recombinant Human SEC14L4 protein

Size: 10µg
Recombinant Human SEC14L4 protein is a Human Full Length protein, in the 1 to 352 aa range, expressed in Wheat germ, suitable for ELISA, WB.
Key facts
Expression system:Wheat germ,
Tags:GST tag N-Terminus,
Applications:ELISA, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Biologically active:No,
Accession:Q9UDX3,
Animal free:No,
Carrier free:No,
Species:Human,
Storage buffer:pH: 8Constituents: 0.79% Tris HCl, 0.31% Glutathione

Properties and Storage Information:
Shipped at conditions-Dry Ice, Appropriate short-term storage conditions--80°C, Appropriate long-term storage conditions--80°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
SEC14L4 also known as SEC14-like protein 4 is a protein involved in lipid metabolism and intracellular transport. It is a member of the SEC14 superfamily and functions as a lipid and phospholipid transfer protein. SEC14L4 has a molecular mass of approximately 63 kDa. The protein is expressed in several tissues including liver and brain with expression levels that vary depending on the tissue type.
Biological function summary
SEC14-like function is associated with the regulation of lipid homeostasis and intracellular trafficking. It operates within the endoplasmic reticulum and Golgi apparatus participating in lipid transfer processes important for maintaining cellular lipid balance. SEC14L4 does not typically form part of larger protein complexes but interacts with membrane lipids to perform its role in the cell.
Pathways
SEC14L4 is involved in the phospholipid metabolic and vesicle-mediated transport pathways. It is closely associated with the function of proteins such as phosphatidylinositol 4-kinase and its role in maintaining the phosphoinositide pool which is critical for vesicular trafficking in the cell. These pathways are essential for cellular homeostasis and organelle function.
SEC14L4 has been implicated in neurological conditions such as potential connections to Alzheimer's disease where lipid transport imbalance appears to play a role. The protein also shows relevance in metabolic disorders such as fatty liver disease linked to disruptions in lipid homeostasis. SEC14L4 may interact with proteins involved in these conditions such as tau protein in Alzheimer's disease indicating a possible pathway through which its dysregulation could impact disease progression.