Abcam, ab166349, Recombinant Human SLCO4C1 protein

Size: 10µg
Recombinant Human SLCO4C1 protein is a Human Full Length protein, in the 1 to 724 aa range, expressed in Wheat germ, suitable for ELISA, WB.
Key facts
Expression system:Wheat germ,
Tags:GST tag N-Terminus,
Applications:WB, ELISASee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Biologically active:No,
Accession:Q6ZQN7,
Animal free:No,
Carrier free:No,
Species:Human,
Storage buffer:pH: 8Constituents: 0.79% Tris HCl, 0.31% Glutathione

Properties and Storage Information:
Shipped at conditions-Dry Ice, Appropriate short-term storage conditions--80°C, Appropriate long-term storage conditions--80°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
SLCO4C1 also known as organic anion transporter 4C1 is part of the solute carrier organic anion transporter family. It functions in transporting organic anions across cell membranes. This protein facilitates the movement of drugs and endogenous molecules playing a role in pharmacokinetics and detoxification processes. It is around 80 kDa in size. SLCO4C1 is mainly expressed in the kidney and heart which indicates its influence on renal and cardiac function.
Biological function summary
SLCO4C1 is involved in the cellular uptake and clearance of various organic compounds including toxins and drugs. It does not form part of any larger protein complexes but functions as an integral membrane transporter. This transport activity impacts cellular homeostasis and contributes to the regulation of substances in physiological environments balancing the distribution of substrates across membranes effectively.
Pathways
SLCO4C1 participates in the organic anion transport pathway. This pathway is important in processes like drug metabolism and elimination. It interacts with other solute carrier family members to ensure effective transport of a variety of molecules. Proteins such as SLCO1B1 are related to SLCO4C1 through shared functions in this pathway impacting drug clearance and removal from the bloodstream.
SLCO4C1 plays a role in hypertension and chronic kidney disease. Alterations in SLCO4C1 expression or function can affect blood pressure regulation and kidney function due to its role in transporting signaling molecules and drugs that impact vascular health. It is also linked to the activity of transporters like SLCO2B1 which can modify the pharmacokinetics of medications influencing therapeutic outcomes and risks in these conditions.