Abcam, ab166788, Anti-SEPT4 antibody

Size: 50µg
Goat Polyclonal SEPT4 antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 5 publications. Immunogen corresponding to Synthetic Peptide within Human SEPTIN4 aa 400-450.
Key facts
Host species:Goat,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human SEPTIN4 aa 400-450. The exact immunogen used to generate this antibody is proprietary information.O43236,
Specificity:ab166788 is expected to recognize isoform 1 (NP_004565.1), 3 (NP_536341.1) and 4 (NP_001185642.1) of Human SEPT4.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.3Preservative: 0.02% Sodium azideConstituents: 99% Tris buffered saline, 0.5% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
SEPT4 also known as septin 4 or PC-Tse1 is a member of the septin family of GTP-binding proteins which have roles in cytoskeletal organization. This protein has a molecular mass of approximately 48 kDa and is expressed in various tissues including the brain and testes. SEPT4's mechanical function involves forming hetero-oligomeric complexes that contribute to cellular processes like cytokinesis where it helps in cytokinetic abscission during cell division. Its presence in diverse cell types reflects its role in maintaining cellular architecture and integrity.
Biological function summary
SEPT4 functions as part of the septin complex which is important for cytoskeletal remodeling and membrane dynamics. It interacts with other septins to form filamentous structures that organize cellular compartments and ensure membrane rigidity and shape. SEPT4 also plays a role in apoptosis particularly in promoting the mitochondrial pathway of apoptotic cell death. Its ability to localize to mitochondria and influence mitochondrial morphology underlines its involvement in cellular stress responses.
Pathways
SEPT4 engages in significant interactions in the apoptosis and cell cycle pathways. Within the apoptosis pathway SEPT4 influences mitochondrial cytochrome c release indirectly associating with proteins like BCL2 which regulates cell death. In the cell cycle pathway SEPT4's role in cytokinesis highlights its interaction with kinases that govern cell division checkpoints. These pathways emphasize SEPT4's dual role in controlling both cell structure and survival.
SEPT4 has been linked to neurodegenerative diseases and cancer. In Parkinson's disease SEPT4 interacts with proteins like Parkin where it influences the clearance of damaged mitochondrial components suggesting a protective role against neurodegeneration. In the context of cancer aberrations in SEPT4 expression or function can lead to improper cell division potentially contributing to tumorigenesis. Its involvement in such diverse conditions highlights SEPT4's importance in disease pathogenesis and highlights its potential as a therapeutic target.