Abcam, ab167377, Anti-CHD2 antibody

Size: 50µg
Mouse Polyclonal CHD2 antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human CHD2.
Key facts
Host species:Mouse,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IF, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Full Length Protein corresponding to Human CHD2.O14647

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The CHD2 protein also known as Chromodomain-Helicase-DNA-binding protein 2 acts as an ATP-dependent chromatin remodeler. This protein has a mass of approximately 210 kDa. CHD2 is expressed in various tissues with higher expression levels noted in the brain and skeletal muscle. As a part of the chromatin remodeling family CHD2 plays a role in modifying the structure of chromatin to affect gene expression.
Biological function summary
CHD2 contributes to DNA repair and transcription regulation by modifying chromatin structure. It is a part of the CHD family of chromatin remodelers which influences nucleosome positioning and accessibility. By facilitating transcription CHD2 impacts gene expression necessary for neural development and other processes. CHD2 functions as a monomer and does not form larger protein complexes.
Pathways
CHD2 influences gene expression regulation and neural development. It plays a role in the transcriptional regulation pathway by interacting with chromatin to control the accessibility of transcription factors. The protein links with others like CHD3 and CHD4 within this pathway to coordinate chromatin conformation changes necessary for proper transcription processes.
The CHD2 protein relates to epileptic encephalopathy and neurodevelopmental disorders. Mutations in the CHD2 gene associate with these conditions affecting neurological function and development. CHD2 mutations often coexist with other genetic factors involving proteins like SCN1A contributing to the complex nature of these disorders.