Abcam, ab167650, Anti-Thymosin beta 4 antibody

Size: 50µg
Mouse Polyclonal Thymosin beta 4 antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 7 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human TMSB4X.
Key facts
Host species:Mouse,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Full Length Protein corresponding to Human TMSB4X.P62328

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Thymosin beta 4 is a small actin-binding peptide known for its role in the regulation of actin polymerization and depolymerization. Sometimes called Tβ4 or beta thymosin this peptide has a mass of approximately 5 kDa. It is widely expressed in various tissues especially in wound sites circulatory system and the central nervous system. The peptide consists of 43 amino acids and its structure allows it to sequester actin monomers influencing the cytoskeleton dynamics within cells.
Biological function summary
Thymosin beta 4 influences several cellular processes including cell migration proliferation and differentiation. It is not part of a large complex but directly interacts with actin to modulate its behavior. Through its regulation of actin filament formation it plays a significant role in wound healing tissue regeneration and inflammatory responses. Furthermore it contributes to the migration of endothelial cells highlighting its importance in angiogenesis.
Pathways
Thymosin beta 4 contributes significantly to cell motility and the vascular endothelial growth factor (VEGF) pathway. It interacts with the protein profilin in the regulation of actin dynamics impacting cellular processes like cell movement and angiogenesis. By influencing these pathways Thymosin beta 4 aids in the body's repair mechanisms providing cellular structural support under varying physiological conditions.
Thymosin beta 4 is associated with cardiovascular diseases and fibrotic disorders. It has a potential protective effect in ischemic heart disease where it contributes to heart repair by modulating actin and promoting endothelial cell migration. In fibrosis its regulatory effects on actin filaments may impact the excessive tissue scarring. Thymosin beta 4 also interacts with proteins like beta-adrenoreceptors during cardiovascular stress responses demonstrating its multi-faceted role in health and disease.