Abcam, ab168243, Anti-COP antibody

Size: 50µg
Mouse Polyclonal COP antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human CARD16.
Key facts
Host species:Mouse,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Full Length Protein corresponding to Human CARD16.Q5EG05

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
COP also known as coat protein complex refers to a group of proteins involved in vesicle formation. These proteins are part of coatomer protein complexes like COPI and COPII which play roles in transport within cells. COP proteins have an approximate mass of 600-700 kDa depending on the specific complex. Inside the cell COP proteins are expressed in the Golgi apparatus and endoplasmic reticulum. In research the term 'COP mouse' and related terms like 'mouse COP' often emerge referring to studies in model organisms like mice to understand these proteins' functions better.
Biological function summary
COP proteins regulate intracellular transport by forming vesicles that shuttle materials between organelles. COPI is predominantly involved in retrograde transport from the Golgi to the endoplasmic reticulum while COPII handles anterograde transport from the endoplasmic reticulum to the Golgi. These coatomer complexes are vital components of the cellular sorting machinery affecting the flow of lipids and proteins within cells. The function of COP proteins influences cellular processes maintaining cellular organization and proper protein localization.
Pathways
COP proteins integrate into intracellular transport processes that impact various signaling pathways. COPI for example operates within the vesicular transport pathway contributing to the recycling of proteins. Notably COPII is important in the secretory pathway impacting the export of proteins from the endoplasmic reticulum. This activity involves coordination with other proteins like SNAREs which facilitate vesicle fusion and delivery of contents to target membranes.
Defective COP function links to certain conditions such as cranio-lenticulo-sutural dysplasia and congenital dyserythropoietic anemia. Dysfunction in COPII proteins including Sec23 and Sec24 associates with cranio-lenticulo-sutural dysplasia demonstrating its role in maintaining correct protein trafficking. Additionally mutations impacting COPI proteins tie to congenital dyserythropoietic anemia revealing the relevance of vesicle transport in blood cell formation. Understanding connections between COP proteins and these diseases aids in elucidating the cellular transport's role in human health.