Abcam, ab168273, Anti-SSBP2 antibody

Size: 50µg
Mouse Polyclonal SSBP2 antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human SSBP2.
Key facts
Host species:Mouse,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Full Length Protein corresponding to Human SSBP2.P81877

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Single-stranded DNA-binding protein 2 (SSBP2) also known as hSSB2 is a protein with a molecular mass of approximately 38 kDa. This protein plays a role in binding to single-stranded DNA. It is highly expressed in hematopoietic tissues including bone marrow and blood cells. SSBP2 also shows distinct expression in multiple human tissues highlighting its importance across different cellular environments. Mechanistically SSBP2 stabilizes single-stranded DNA by preventing the formation of secondary structures which is critical during DNA replication and repair.
Biological function summary
SSBP2 functions as a part of the multi-protein complex important for DNA metabolism and maintenance of genomic stability. It plays a role in the transcriptional activation of several tumor suppressor genes by interacting with other single-stranded DNA-binding partners. The protein influences cell cycle regulation by modulating the expression of genes involved in cell division and proliferation. This biological action affirms SSBP2's contribution to maintaining normal cellular functions and preventing abnormal cellular growth.
Pathways
The involvement of SSBP2 in cell cycle regulation and DNA repair underlines its participation in pathways like p53 signaling and homologous recombination. SSBP2 connects with proteins like RPA which is central to DNA metabolism to ensure accurate DNA replication and repair. These interactions place SSBP2 in a critical position to respond to and repair DNA damage thereby maintaining cellular integrity and genomic stability.
SSBP2 has relevance in leukemia and breast cancer. Its reduced expression or inactivity correlates with the progression of these diseases. In leukemia SSBP2's interaction with tumor suppressor proteins such as pRB is significant. In breast cancer its dysregulation can lead to unchecked cell proliferation. Understanding these relationships provides insight into SSBP2's potential as a biomarker and therapeutic target in cancer research.