Abcam, ab168279, Anti-HOXB1 antibody

Size: 50µg
Mouse Polyclonal HOXB1 antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human HOXB1.
Key facts
Host species:Mouse,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IF, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Full Length Protein corresponding to Human HOXB1.P14653

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
HOXB1 also known as Homeobox B1 is a transcription factor that plays an important role in early developmental processes. It belongs to the homeobox family and has a molecular weight of about 31 kDa. This protein is highly expressed in embryonic tissues particularly in the hindbrain region and is important for segmental identity in this area during development. As its expression is tightly regulated precise control ensures correct hindbrain patterning.
Biological function summary
HOXB1 functions as a regulator of gene expression during development. It acts in concert with other homeobox genes to establish and maintain the identity of specific cell types. HOXB1 is part of a larger complex of proteins that modulates chromatin structure aiding in transcriptional control. This interaction allows it to impact cellular differentiation processes dictating specific neuronal fates important for normal brain structure.
Pathways
HOXB1 operates within significant developmental pathways such as the retinoic acid signaling pathway which influences cell growth and differentiation. This protein also interacts with HOXA1 a related homeobox protein highlighting its role in gene regulatory networks that dictate neuronal patterning and differentiation. Such functional interactions place HOXB1 as an important node within the gene regulatory networks involved in development.
Improper expression or mutations in HOXB1 can lead to congenital facial malformations such as Bosley-Salih-Alorainy syndrome. Its involvement in this genetic disorder adds to its significance in craniofacial development. HOXB1 has also been associated with hindbrain malformations when expressed abnormally. Its interaction with other key developmental proteins like PAX6 further emphasizes its role in maintaining normal developmental processes and providing targets for understanding developmental disorders.