Abcam, ab168351, Anti-NgBR antibody [EPR8668]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal NGBR antibody. Suitable for WB and reacts with Human, Mouse, Rat samples. Cited in 13 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR8668,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
This antibody was developed as part of a collaboration between Epitomics, the National Institutes of Health and the lab of Qing (Robert) Miao from the Medical College of Wisconsin.
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
NgBR also known as the Nogo-B receptor is a transmembrane protein with an approximate mass of 38 kDa. It plays a role in cellular mechanisms especially within endothelial cells where it is expressed abundantly. NgBR involves itself in modulating the activity and localization of certain enzymes particularly in processes requiring lipid modification. Expression of NgBR can also be found in other tissues suggesting a broader range of functions.
Biological function summary
NgBR engages in various cellular operations influencing development survival and migration of cells. It acts as a cofactor for enzymes participating in dolichol biosynthesis and cholesterol synthesis. NgBR often forms a complex with other proteins to execute these roles. By interacting with Nogo-B NgBR impacts key angiogenesis and vascular homeostasis decisions playing part in growth and maintenance of blood vessels.
Pathways
NgBR aligns itself with the PI3K-Akt signaling cascade and the Ras pathway both important in cellular proliferation and survival. In these pathways NgBR associates closely with PI3K and interacts with Ras proteins enabling effective signal transduction. NgBR's contribution helps maintain cellular responses to growth signals and ensures proper functioning of cellular mechanisms.
Altered expression or function of NgBR associates with various pathologies including cancer and cardiovascular diseases. NgBR's connection to cancer lies in its involvement with endothelial survival and proliferation with disruptions potentially leading to tumor growth and metastasis. In cardiovascular disease NgBR plays a role in endothelial dysfunction linking with proteins such as Nogo-B which influences blood vessel repair and formation hinting at implications in atherosclerosis and related disorders.