Abcam, ab168678, Anti-UXT antibody

Size: 50µg
Mouse Polyclonal UXT antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human UXT.
Key facts
Host species:Mouse,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IF, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Full Length Protein corresponding to Human UXT.Q9UBK9

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The UXT protein also known as ubiquitously expressed transcript protein plays a role in cellular homeostasis by interacting with nucleic acids and other proteins. The mass of UXT is approximately 18 kDa. It expresses ubiquitously across various tissues indicating its fundamental role in basic cellular processes. UXT involves itself in several cellular functions providing stability and immunity at the cellular level.
Biological function summary
This protein participates in transcription regulation by forming part of the larger transcriptional coregulator complex. UXT enhances the transcriptional machinery's efficiency impacting the expression of genes critical for cell cycle and survival. It coordinates with heat shock proteins possibly preventing protein denaturation and other stress responses. Its involvement across different cell types emphasizes its multifaceted role in maintaining cellular integrity.
Pathways
The UXT protein impacts transcriptional regulation and stress response pathways. It directly influences the NF-kB signaling pathway which is important for immune response and inflammation. The UXT protein also interacts with components like RelA/p65 modulating inflammatory gene expression. Moreover UXT integrates into the androgen receptor signaling pathway linking it to hormonal regulation and reproductive biology. Its connections in these pathways highlight its regulatory potential in diverse biological contexts.
UXT has associations with cancer and neurodegenerative diseases. Altered UXT expression links to certain carcinomas suggesting its role in tumorigenesis through transcriptional deregulation. UXT's interaction with proteins like p53 which influences cell cycle and apoptosis can affect cancer progression. Additionally UXT plays a part in neurodegenerative disease mechanisms although the exact pathways remain less defined. UXT's involvement in protein folding and preventing protein denaturing might explain its connection to neurodegenerative processes where misfolded proteins contribute to disease pathology.