Abcam, ab168829, Anti-NKRF antibody

Size: 100µg
Rabbit Polyclonal NKRF antibody. Suitable for IHC-P, IP, WB and reacts with Human samples. Cited in 6 publications. Immunogen corresponding to Synthetic Peptide within Human NKRF aa 50-100.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, WB, IPSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human NKRF aa 50-100. The exact immunogen used to generate this antibody is proprietary information.O15226

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Purification notes-ab168829 was affinity purified using an epitope specific to NKRF immobilized on solid support., Storage buffer-pH: 7 - 8Preservative: 0.09% Sodium azideConstituents: 99% Tris citrate/phosphate, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Aliquoting information-Upon delivery aliquot

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
NKRF also known as NF-kappa-B repressing factor functions as a transcriptional repressor. This protein weighs approximately 85 kDa and appears in various tissues with higher expression in the spleen thymus and lungs. NKRF interacts with NF-kB elements in DNA inhibiting the transcription of specific genes especially those related to immune responses and inflammation.
Biological function summary
NKRF plays an important role in modulating inflammation and immune responses. It forms part of a complex that controls the transcriptional activity of NF-kappa-B an important transcription factor in these processes. By repressing unwanted NF-kappa-B signal NKRF prevents excessive immune response and inflammation contributing to cellular homeostasis and protecting tissues from damage.
Pathways
NKRF functions prominently in the NF-kappa-B signaling and inflammatory pathways. Within these pathways it regulates the activity of related proteins such as RelA/p65 which are components of the NF-kappa-B family. NKRF balances the inflammation by downregulating the genes activated by NF-kB making sure the response stays controlled.
NKRF is critical in conditions associated with chronic inflammation. High or low levels of NKRF correlate with diseases such as asthma and rheumatoid arthritis. In asthma NKRF may modulate the activity of pro-inflammatory cytokines while in rheumatoid arthritis it may interact with upstream molecules like IKK complex to control inflammation.