Abcam, ab168960, Anti-Solute carrier family 22 member 18 antibody

Size: 50µg
Mouse Polyclonal Solute carrier family 22 member 18 antibody. Suitable for WB and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human SLC22A18.
Key facts
Host species:Mouse,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Full Length Protein corresponding to Human SLC22A18.Q96BI1

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Solute carrier family 22 member 18 (SLC22A18) also known as BWR1A is a transporter protein that plays a role in moving organic cations across cell membranes. It is a member of the solute carrier family 22 which includes several transporters that facilitate the movement of various molecules. The molecular mass of SLC22A18 is approximately 61 kDa. It is mostly expressed in tissues such as the kidney placenta and liver where it contributes to the regulation of extracellular and intracellular concentrations of organic ions.
Biological function summary
SLC22A18 functions in the uptake and extrusion of organic cations impacting cellular homeostasis and metabolism. It is not part of a complex but instead works individually within the cells. This protein helps in maintaining the balance of metabolites and xenobiotics substances foreign to an organism's body influencing processes including detoxification and metabolic regulation.
Pathways
SLC22A18 participates in the organic cation transport pathway and the xenobiotic metabolism pathway. It is related to proteins in these pathways such as other solute carriers which together maintain the transport of various cations and metabolites across cellular membranes. This action assists various cells in handling foreign substances by regulating their uptake and excretion to adapt to various internal and external environments.
SLC22A18 has associations with cancer and metabolic syndrome. Changes in its expression or function can affect cellular detoxification abilities which may lead to the development of certain cancers due to an accumulation of harmful compounds. In metabolic syndrome altered SLC22A18 function can disturb normal metabolism. This protein interacts with other solute carriers and transporters to influence disease progression through its key role in transporting critical molecules within the body.