Abcam, ab169042, Anti-SCO2 antibody

Size: 50µg
Mouse Polyclonal SCO2 antibody. Suitable for WB and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human Protein SCO2 homolog, mitochondrial.
Key facts
Host species:Mouse,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Full Length Protein corresponding to Human Protein SCO2 homolog, mitochondrial.O43819

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Synthesis of cytochrome c oxidase 2 (SCO2) is a mitochondrial protein essential for the formation of cytochrome c oxidase complex also known as complex IV of the electron transport chain. SCO2 has a molecular weight of approximately 29 kDa. This protein is expressed mainly in tissues with high energy demands such as the heart brain and skeletal muscles. It functions within the mitochondria playing a direct role in the maturation of the copper centers of cytochrome c oxidase which is important for the enzyme's proper function.
Biological function summary
SCO2 ensures efficient oxidative phosphorylation by participating in the assembly and maintenance of complex IV a critical component of the electron transport chain. It associates with other assembly factors and proteins to deliver copper ions to their designated sites within cytochrome c oxidase. By facilitating proper assembly SCO2 supports efficient electron transfer through the respiratory chain ultimately leading to ATP production.
Pathways
SCO2 is intimately involved in mitochondrial respiratory pathways particularly the oxidative phosphorylation pathway. This pathway is fundamental for ATP production under aerobic conditions. SCO2 interacts with proteins such as COX17 and COX20 which also participate in the copper delivery and assembly of cytochrome c oxidase. This interaction ensures the transfer of electrons from NADH and FADH2 to oxygen a process that generates a proton gradient used by ATP synthase for ATP synthesis.
Defects in SCO2 relate to conditions such as Leigh syndrome and hypertrophic cardiomyopathy. Leigh syndrome a severe neurological disorder emerges from impaired energy production due to dysfunctional cytochrome c oxidase assembly in which defective SCO2 plays a significant part. SCO2 also associates with disorders involving other proteins like SCO1 and SURF1 both of which contribute to the pathology of cytochrome c oxidase deficiencies manifesting in severe metabolic and multisystemic disorders.