Abcam, ab169455, Anti-GPCR GPR34 antibody

Size: 50µg
Mouse Polyclonal GPCR GPR34 antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human Probable G-protein coupled receptor 34.
Key facts
Host species:Mouse,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IF, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Full Length Protein corresponding to Human Probable G-protein coupled receptor 34.Q9UPC5

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
GPR34 also known as G-protein coupled receptor 34 is a member of the GPCR family. This receptor has a mass of approximately 44-48 kDa. It localizes mainly to cell membranes due to its seven transmembrane domains characteristic of GPCRs. GPR34 expression has been widely observed in the immune system particularly in immune cells such as macrophages and dendritic cells but it also appears in tissues like the spleen and brain. This suggests its involvement in key physiological processes.
Biological function summary
GPR34 plays a role in the regulation of immune responses and potential modulation of inflammation. It does not explicitly belong to any known receptor complex but works individually to transduce signals from extracellular to intracellular environments. This receptor can influence the behavior of cells by affecting cytokine production and trafficking of immune cells bringing about changes in immune system activity.
Pathways
GPR34 is involved in signaling cascades that impact the phosphatidylinositol signaling system. This pathway is important for several cellular processes including growth metabolism and cell survival. GPR34 shares functional similarities with other GPCRs involved in similar pathways such as GPR18 which also plays roles in immune function modulation. These pathways highlight the importance of GPR34 in maintaining immune homeostasis and offering a platform for potential therapeutic targeting.
GPR34 has been linked to inflammatory diseases and is suspected to contribute to conditions like asthma and rheumatoid arthritis. Its expression pattern and signaling pathways suggest a role in the development and progression of these disorders. GPR34 modulation can impact inflammatory cytokines and chemokine production. Scientists have studied GPR34 in relation to diseases to explore its potential as a therapeutic target. Additionally its interactions with proteins like other GPCRs or inflammatory mediators could provide further insight into disease mechanisms and possible intervention points.