Abcam, ab169514, Anti-CEMP1 antibody

Size: 50µg
Mouse Polyclonal CEMP1 antibody. Carrier free. Suitable for WB and reacts with Transfected cell lysate - Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human CEMP1.
Key facts
Host species:Mouse,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:Yes,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Full Length Protein corresponding to Human CEMP1.Q6PRD7

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
CEMP1 also known as Cementum protein 1 is a protein with an approximate mass of 39 kDa. It localizes mainly in the cementum of teeth but is also found in the periodontal ligament. CEMP1 engages in the mineralization process of cementum an important tissue that provides support and stability to teeth by anchoring them to the jawbone. The expression of CEMP1 occurs in cementoblasts cells responsible for generating and maintaining cementum.
Biological function summary
The function of CEMP1 in dental tissues extends beyond just promoting mineralization. It acts as a regulator of cell differentiation and proliferation which are critical stages in tissue development and repair. In the context of tooth development CEMP1 does not belong to a larger protein complex but interacts with the extracellular matrix to maintain the structural integrity of the periodontal tissues. This involvement highlights its importance in dental health.
Pathways
CEMP1 plays a role in signaling pathways related to osteogenesis and extracellular matrix organization. It interacts with molecular components in the Wnt signaling pathway an important pathway involved in bone formation and cell proliferation. CEMP1 also functions in tandem with proteins like osteopontin contributing to the control of mineral deposition and tissue homeostasis within the periodontium.
CEMP1's function offers important insights into conditions like periodontal disease and cleidocranial dysplasia. In periodontal disease where inflammation and destruction of supporting tooth tissues occur CEMP1's role in cementum integrity suggests it may influence disease progression. Additionally it may relate to collagen type I whose expression is important in maintaining the extracellular matrix affected in such disorders. Understanding CEMP1's interactions might offer potential therapeutic targets to manage these conditions and enhance periodontal regeneration.