Abcam, ab169523, Anti-ADRA1B antibody [EPR10336]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal ADRA1B antibody. Suitable for WB, IHC-P and reacts with Human, Mouse, Rat samples. Cited in 25 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR10336,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Rat, Human,
Applications:WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
ADRA1B also known as alpha-1B adrenergic receptor is a G protein-coupled receptor (GPCR) involved in various cellular processes. It has a molecular mass of approximately 56 kDa. ADRA1B mainly expresses in smooth muscle cells particularly within arterial walls and cardiac tissues which suggests its involvement in cardiovascular function. It also expresses in the central nervous system reflecting a broader physiological role.
Biological function summary
Alpha-1B adrenergic receptor mediates vasoconstriction and regulates blood pressure by interacting with catecholamines like norepinephrine. This receptor participates in forming a homodimer or a heterodimer complex with other adrenergic receptors which affects its signaling capabilities and functional outcomes. The receptor's activation influences smooth muscle contraction cardiac output and alpha-adrenergic signaling.
Pathways
ADRA1B actively participates in the adrenergic signaling pathway influencing cardiovascular regulation and smooth muscle contraction. The receptor interacts with proteins such as G proteins which are central to signal transduction. It also relates to the mitogen-activated protein kinase (MAPK) pathway promoting cell proliferation and survival linking its function to both cardiac and neural activities.
ADRA1B associates with hypertension and heart failure where its overexpression or dysregulation affects vascular resistance and cardiac workload. It connects to proteins like phospholipase C which further modulate intracellular calcium levels linked to these cardiovascular conditions. Additionally changes in this receptor's function may relate to psychiatric disorders reflecting its role in the central nervous system and interactions with noradrenergic pathways.