Abcam, ab169577, Anti-SNIP1 antibody

Size: 50µg
Mouse Polyclonal SNIP1 antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human SNIP1.
Key facts
Host species:Mouse,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Full Length Protein corresponding to Human SNIP1.Q8TAD8

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
SNIP1 also known as Smad nuclear interacting protein 1 is a nuclear protein with a mass of approximately 43 kDa. This protein mechanically functions as a nuclear co-repressor that interacts with Smad proteins and the transcription factor c-Myc. SNIP1 is expressed in various tissues notably in embryonic and adult brain tissues which indicates a role in development and cellular regulation within these areas.
Biological function summary
SNIP1 influences transcriptional repression by modulating the transcriptional activity of the Smad4 complex. SNIP1 interacts with several regulatory proteins to modulate gene expression. By inhibiting the transcriptional activity of Smad proteins SNIP1 can regulate various genes involved in cell growth and proliferation affecting how cells behave in different contexts.
Pathways
SNIP1 participates in important cellular signaling pathways such as the TGF-beta and BMP signaling pathways. SNIP1 interacts with proteins in these pathways including Smad2 and Smad3 to control cellular responses to growth factors. By influencing these pathways SNIP1 plays a part in cellular processes like apoptosis and differentiation.
SNIP1 has implications in cancer and neurodevelopmental disorders. In cancer SNIP1's interaction with proteins like c-Myc and Smad3 plays a role in tumor progression highlighting its involvement in oncogenic pathways. In neurodevelopmental disorders altered SNIP1 expression affects normal brain development suggesting links between its expression and conditions such as autism spectrum disorders.