Abcam, ab169587, Anti-Zinc finger protein 668 antibody

Size: 50µg
Mouse Polyclonal Zinc finger protein 668 antibody. Suitable for WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human ZNF668.
Key facts
Host species:Mouse,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Full Length Protein corresponding to Human ZNF668.Q96K58

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Zinc finger protein 668 also known as ZNF668 is a transcription factor that contains zinc finger domains which allow it to bind to specific DNA sequences. This protein has a mass of approximately 82 kDa. Scientists have observed its expression in various tissues often higher in certain regions of the brain and testes. ZNF668 plays a significant role in regulating gene expression by interacting directly with DNA influencing cellular processes through transcriptional regulation.
Biological function summary
Zinc finger protein 668 modulates important gene networks involved in cell proliferation and differentiation. It functions not independently but as part of a larger transcriptional complex engaging in interactions with other proteins that enable it to effectively regulate gene expression. By binding to DNA ZNF668 can activate or repress the transcription of specific target genes impacting cellular functions and maintaining homeostasis.
Pathways
Researchers place zinc finger protein 668 within the p53 signaling pathway influencing cell cycle regulation and apoptosis. The interactions of ZNF668 with p53-related proteins contribute to its role in DNA damage response and maintaining genomic stability. Another important pathway involving ZNF668 is the Wnt signaling pathway where it interacts with other pathway components to modulate cell fate determination and embryonic development processes.
Zinc finger protein 668 has connections to certain cancers including breast cancer where its dysregulation can contribute to tumorigenesis. Altered expression of ZNF668 may impact its interactions with p53 and other oncogenic proteins such as MDM2 leading to uncontrolled cell growth. Additionally abnormalities in ZNF668 activity relate to neurological disorders possibly due to its expression in the brain and roles in neural differentiation pathways.