Abcam, ab169672, Anti-EXD2 antibody

Size: 50µg
Mouse Polyclonal EXD2 antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human EXD2.
Key facts
Host species:Mouse,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IF, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Full Length Protein corresponding to Human EXD2.Q9NVH0

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
EXD2 also known as Exoribonuclease 2 is an exoribonuclease enzyme with a molecular mass of approximately 72 kDa. It is found mainly in the mitochondria where it helps ensure mitochondrial RNA stability. This enzyme carries out 3'-5' exoribonuclease activity cleaving RNA substrates to maintain proper mitochondrial function. Researchers observe its expression in several tissues with pronounced levels noticed in highly energy-dependent tissues such as muscle and brain where mitochondrial efficiency is important.
Biological function summary
The enzyme plays a significant role in mitochondrial RNA metabolism. EXD2 participates in RNA degradation essential for the integrity of mitochondrial gene expression. It does not function in isolation; instead it forms complexes with other mitochondrial RNA-binding proteins to execute its nuclease activity efficiently. These interactions help regulate the turnover of mitochondrial mRNAs ensuring the correct expression levels for mitochondrial proteins.
Pathways
EXD2 holds an integral position in mitochondrial gene expression and oxidative phosphorylation pathways. Within the oxidative phosphorylation pathway EXD2 assists in regulating RNA components required for the synthesis of core subunits of the electron transport chain. Additionally EXD2 interacts with proteins like POLRMT which is necessary for mitochondrial RNA transcription therefore linking RNA metabolism to energy production.
Researchers link EXD2 to mitochondrial diseases and some neurodegenerative disorders. These conditions can arise when EXD2 is dysregulated leading to defects in energy metabolism due to improper mitochondrial function. Mutations or loss of function in EXD2 may associate with reduced oxidative phosphorylation efficiency and symptoms presenting in disorders such as Leigh syndrome. Furthermore disorders involving mitochondrial dysfunction often involve complex interactions with proteins like OPA1 connecting to broader mitochondrial dynamics.