Abcam, ab17018, Anti-FBXL2 antibody

Size: 100µg
Goat Polyclonal FBXL2 antibody. Suitable for IHC-P, WB and reacts with Human, Rat samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human FBXL2 aa 1-50.
Key facts
Host species:Goat,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Rat, Human,
Applications:WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human FBXL2 aa 1-50. The exact immunogen used to generate this antibody is proprietary information.Q9UKC9

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Purification notes-Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide., Storage buffer-pH: 7.3Preservative: 0.02% Sodium azideConstituents: Tris buffered saline, 0.5% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
FBXL2 also known as F-box and leucine-rich repeat protein 2 is involved in protein degradation mechanisms. It is part of a SCF (SKP1-Cullin-F-box) complex and functions as a ubiquitin ligase. FBXL2 targets proteins for ubiquitination tagging them for proteasomal degradation. Weighing approximately 49 kDa FBXL2 shows expression in various tissues including the liver heart and brain. Its role in maintaining protein homeostasis highlights its importance in cellular processes.
Biological function summary
The FBXL2 protein maintains cellular protein quality by regulating the turnover of specific substrates. It forms a complex with SKP1 and Cullin-2 in the ubiquitin-proteasome pathway. FBXL2 mediates the degradation of important regulatory proteins influencing the cell cycle and signal transduction. This activity impacts cellular responses to stress and environmental changes ensuring proper cellular adaptation.
Pathways
FBXL2 participates in the cell cycle and apoptosis regulation pathways. It intersects with the PI3K/Akt signaling pathway where it interacts with proteins like Cyclin D1 and Cdk inhibitors playing a part in cell proliferation and survival. These interactions demonstrate FBXL2's important role in controlling cell growth and division affecting how cells respond to intrinsic and extrinsic signals.
FBXL2 connects to cancer and neurodegeneration. In cancer FBXL2 may impact tumor progression due to its role in modulating oncogenic pathways interacting with proteins like mTOR which regulate cell growth. Additionally in neurodegenerative diseases FBXL2 affects protein aggregation processes which are relevant in conditions like Alzheimer's disease by targeting specific substrates for degradation. This connection to key disease mechanisms highlights FBXL2 as a significant focus for therapeutic research.