Abcam, ab170888, Anti-FHIT antibody [EPR10931]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal FHIT antibody. Suitable for WB and reacts with Human, Rat samples. Cited in 4 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR10931,
Isotype:IgG,
Carrier free:No,
Reacts with:Rat, Human,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Species reactivity
Mouse: We have preliminary internal testing data to indicate this antibody may not react with this species.
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contact us
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Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purity-Tissue culture supernatant, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The 'FHIT' protein also known as the Fragile Histidine Triad protein weighs about 16.8 kDa. It is a tumor suppressor and is widely expressed in various tissues including the lungs kidneys and pancreas. FHIT is encoded by the FHIT gene located on chromosome 3 specifically at a common fragile site. The protein plays an important role in maintaining genomic integrity and preventing tumorigenesis. It acts as a diadenosine triphosphate hydrolase breaking down dinucleoside polyphosphates.
Biological function summary
The FHIT protein interacts with other cellular proteins to regulate apoptosis and cell proliferation. It is part of several molecular complexes that are involved in cellular stress responses. The FHIT protein binds to other proteins to initiate a cascade of events leading to programmed cell death in cells with damaged DNA. This role is critical because it prevents the development of cancer by eliminating potentially malignant cells before they proliferate.
Pathways
The FHIT protein participates in the DNA damage response and apoptotic pathways. It is related to the p53 signaling pathway a major pathway controlling cell cycle arrest and apoptosis. FHIT is thought to modulate p53 activity promoting apoptosis in response to genotoxic stress. It also synergizes with proteins like PTEN to enhance protective responses against DNA damage helping to regulate cell survival and proliferation.
The FHIT protein has significant implications for cancer particularly lung and esophageal cancers. Studies show that loss of FHIT expression correlates with tumor progression and a poor prognosis in these cancers. The protein's inactivation often pairs with mutations in proteins like p53 which further disrupts cell cycle control and enhances malignant transformation. FHIT serves as a marker for early detection and a potential target for therapeutic intervention.