Abcam, ab170918, Anti-SLAP2 antibody [EPR8083(2)]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal SLAP2 antibody. Suitable for IP, WB, ICC/IF, Flow Cyt (Intra) and reacts with Human samples. Cited in 1 publication.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR8083(2),
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:Flow Cyt (Intra), IP, ICC/IF, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Species reactivity
Mouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species.
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contact us
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Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Src-like adapter protein 2 (SLAP2) also known as SLAP2 functions as an adaptor protein involved in signal transduction. It mediates interactions between membrane receptors and intracellular signaling components. SLAP2 is a protein of approximately 32 kDa and expression levels vary across different tissues including high expression in immune cells such as lymphocytes and macrophages. The protein has SH2 and SH3 domains which allow it to bind to phosphorylated tyrosines on its target proteins facilitating their degradation or modification.
Biological function summary
SLAP2 has a major role in regulating the immune response. By forming complexes with the components of the signal transduction machinery SLAP2 modulates the activity of key receptors such as the T-cell receptor (TCR) and B-cell receptor (BCR). These interactions influence cellular responses such as proliferation differentiation and apoptosis. Through its action SLAP2 acts as a negative regulator preventing overactivation of immune responses and maintaining homeostasis.
Pathways
Studies have shown that SLAP2 participates in both the T-cell receptor signaling pathway and the B-cell receptor signaling pathway. In these pathways SLAP2 interacts with kinases associated with these receptors such as Lck and Fyn influencing downstream signaling events. SLAP2 can inhibit excessive activation of these pathways by promoting the degradation of key signaling molecules ensuring that cells respond appropriately to external signals during immune activation.
SLAP2 has been linked to certain types of cancer and autoimmune diseases. For example alterations in SLAP2 expression or function may contribute to lymphomas where disrupted signaling processes lead to uncontrolled cell growth. In autoimmune diseases aberrant SLAP2 activity could result in improper immune cell activation potentially linked to proteins like ZAP-70 which are also involved in disease modulation. Understanding SLAP2's regulation and interaction with signaling proteins could offer insights for therapeutic interventions in these conditions.