Abcam, ab171088, Anti-TCR beta F1 antibody [8A3]

Size: 200µg
Anti-TCR beta F1 antibody [8A3] (ab171088) is a mouse monoclonal antibody detecting TCR beta F1 in Western Blot, Flow Cytometry, IP, IHC-P, ICC/IF . Suitable for Human, Mouse, .
Key facts
Host species:Mouse,
Clonality:Monoclonal,
Clone number:8A3,
Isotype:IgG1,
Carrier free:No,
Reacts with:Human, Mouse, Primates,
Applications:IHC-P, ICC/IF, WB, Flow Cyt, IPSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Full Length Protein corresponding to Human TRBV7-9. The exact immunogen used to generate this antibody is proprietary information.P04435

Product details:
What is this antibody validated in?
Anti-TCR beta F1 antibody [8A3] (ab171088) is a mouse monoclonal antibody and is validated for use in Western Blot (WB), Flow Cytometry (Flow Cyt), Immunoprecipitation (IP), Immunohistochemistry (IHC-P), Immunocytochemistry/immunofluorescence (ICC/IF) in Human, Mouse, samples.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein G, Storage buffer-Preservative: 0.1% Sodium azideConstituents: PBS, 0.5% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
TCR beta F1 also known as T-cell receptor beta chain is a component of the T-cell receptor (TCR) complex. It plays a vital role in the immune response. The TCR beta F1 protein has a molecular mass of approximately 45 kDa. It is expressed on the surface of T lymphocytes which are white blood cells involved in the adaptive immune system. This protein is required for recognizing antigens presented by major histocompatibility complex (MHC) molecules on antigen-presenting cells.
Biological function summary
The TCR beta F1 chain forms part of the T-cell receptor complex which is necessary for T-cell activation. The complex also includes other components like TCR alpha chain and CD3 proteins. TCR beta F1 interacts with processed antigens bound to MHC molecules triggering intracellular signaling cascades. These cascades result in T-cell proliferation differentiation and cytokine release essential for the immune defense against pathogens and tumors.
Pathways
TCR beta F1 is central to the T-cell receptor signaling pathway. This pathway initiates after antigen recognition activating downstream signaling molecules such as ZAP70 and LCK. These molecules further propagate signals to pathways like the MAPK/ERK pathway influencing cell survival and proliferation. Additionally TCR beta F1 is part of the NFAT signaling pathway coordinating T-cell activation and cytokine gene transcription.
TCR beta F1 has implications in autoimmune diseases and cancers. In autoimmune diseases like rheumatoid arthritis abnormal TCR signaling leads to excessive immune responses against self-antigens. In certain cancers such as leukemia altered TCR beta chain expressions contribute to uncontrolled T-cell proliferation. These conditions showcase the significant role of TCR beta F1 connecting to proteins like CD3 which also participate in these pathological processes.