Abcam, ab171689, Recombinant Human ZNF346 protein

Size: 100µg
Recombinant Human ZNF346 protein is a Human Full Length protein, in the 1 to 294 aa range, expressed in Escherichia coli, with >90%, suitable for SDS-PAGE, Mass Spec.
Key facts
Purity:>90% SDS-PAGE,
Expression system:Escherichia coli,
Tags:His tag N-Terminus,
Applications:Mass Spec, SDS-PAGESee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Biologically active:No,
Accession:Q9UL40,
Animal free:No,
Carrier free:No,
Species:Human,
Storage buffer:pH: 8Constituents: 50% Glycerol (glycerin, glycerine), 1.17% Sodium chloride, 0.32% Tris HCl, 0.03% (R*,R*)-1,4-Dimercaptobutan-2,3-diol

Properties and Storage Information:
Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
ZNF346 also known as Zinc Finger Protein 346 or PNOZ is a small protein with a mass of approximately 34 kDa. This protein contains zinc finger motifs which allow it to bind RNA and influence RNA stability and processing. You can find ZNF346 mainly expressed in the nucleus especially in tissues with high metabolic activity like the brain and muscle. Its main mechanical role is mediating interactions with nucleic acids anchoring itself to RNA through zinc finger domains which are important for its biological functions.
Biological function summary
ZNF346 impacts several processes involving RNA. It participates in cellular mechanisms that preserve RNA integrity and modulate RNA metabolism. ZNF346 often acts as part of larger protein complexes that are important for RNA surveillance and decay pathways. These processes help manage the vast array of RNA transcripts ensuring that only correctly assembled RNA molecules advance to translation. It plays a role in maintaining the stability and efficient functioning of the cellular transcriptome.
Pathways
The protein ZNF346 is an integral component of RNA processing pathways. It has significant interactions within the nonsense-mediated decay (NMD) pathway working alongside proteins such as UPF1 which is an important regulator in this pathway. The role of ZNF346 in RNA decay pathways indicates its involvement in safeguarding the cell from erroneous RNA guaranteeing that faulty transcripts do not disrupt protein synthesis.
ZNF346 associations include neurodegenerative and muscular disorders. Alterations in ZNF346 function might link to brain neurodegeneration due to its expression and activity in brain tissues. It shares functional pathways with proteins such as UPF1 in the context of neurodegenerative processes which involves RNA stability. Furthermore abnormalities in ZNF346 activity could influence muscle tissue homeostasis potentially connecting to muscular dystrophies.