Abcam, ab171799, Anti-RND3 antibody

Size: 50µg
Mouse Polyclonal RND3 antibody. Suitable for WB and reacts with Human samples. Cited in 4 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human RND3.
Key facts
Host species:Mouse,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Full Length Protein corresponding to Human RND3.P61587

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.4 Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
RND3 also known as RhoE is a small GTPase with a molecular mass of approximately 25 kDa. It belongs to the Rho family of GTPases. RND3 lacks intrinsic GTPase activity which makes it constantly bound to GTP. This protein gets expressed in several tissues including the brain heart and skeletal muscles. By interfering with the actin cytoskeleton RND3 regulates cell shape and movement.
Biological function summary
The functions of RND3 involve the regulation of the cytoskeleton contributing to processes such as cell adhesion and migration. RND3 operates independently not forming part of a larger protein complex yet it plays a pivotal role in modulating the activity of other signaling molecules. Its influence on the cytoskeleton makes it an important player in maintaining cellular architecture and dynamics which is fundamental for tissue integrity and repair.
Pathways
RND3 is intricately involved in the MAPK and PI3K/AKT signaling pathways. These pathways are essential for cell growth migration and survival. RND3 interacts with proteins such as ROCK1 and ROCK2 in these pathways affecting downstream activities positively or negatively. The regulation of these signaling cascades by RND3 shows its importance in cellular responses to environmental cues.
RND3 is linked to cancer and cardiovascular diseases. Alterations in RND3 expression or function can contribute to the uncontrolled cell proliferation seen in various cancers. In cancer its interactions with signaling proteins like AKT lead to enhanced survival signaling. In the context of cardiovascular diseases RND3 influences vascular smooth muscle cell behavior impacting atherosclerosis progression. Through these connections RND3 emerges as a significant target for therapeutic research.