Abcam, ab171943, Anti-SGSM1/RUTBC2 antibody [EPR11563]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal SGSM1/RUTBC2 antibody. Suitable for WB, ICC/IF, Flow Cyt (Intra) and reacts with Human, Mouse, Rat samples. Cited in 2 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR11563,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, Flow Cyt (Intra), ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purity-Tissue culture supernatant, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
SGSM1 also known as RUTBC2 serves as a Rab GTPase-activating protein. It has a mass of approximately 109 kDa. This protein interacts with small GTPases of the Rab family which are pivotal in intracellular vesicle trafficking. SGSM1/RUTBC2 catalyzes the hydrolysis of GTP to GDP on Rab proteins. This activity impacts the regulation of vesicular transport processes. SGSM1/RUTBC2 expression is seen in various tissues indicating its functional diversity.
Biological function summary
SGSM1/RUTBC2 modulates vesicular trafficking and membrane dynamics. It is not part of a large complex but acts as a solitary enzyme influencing membrane trafficking by its interaction with Rabs. Specifically it regulates endocytic and exocytic pathways. Rabs act as molecular switches cycling between active GTP-bound and inactive GDP-bound states and SGSM1 helps facilitate this conversion impacting cellular transport and membrane dynamics.
Pathways
SGSM1/RUTBC2 plays a significant role in endocytic recycling and autophagy pathways. It interacts with Rab7 an important player in the late endocytic pathway and Rab32 integral to lysosomal function. Through mediating the activity of these Rabs SGSM1 influences the trafficking and recycling of membrane proteins and can affect a generation of autophagosomes. This regulation ensures correct cargo delivery and recycling maintaining cellular homeostasis.
SGSM1/RUTBC2 has been associated with neurodegenerative conditions and cancer. Alterations in its expression or function could contribute to improper vesicular transport impacting cellular health and homeostasis. In Alzheimer’s disease dysfunctions of Rab activity influenced by SGSM1 have been noted. Additionally its link to Rab7 suggests a potential involvement in cancer progression as Rab7 dysregulation can affect tumor cell migration and metastasis. Understanding SGSM1 interactions provides insights into these pathologies potentially offering therapeutic targets.