Abcam, ab171946, Anti-RD3 antibody [EPR12169(B)]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal RD3 antibody. Suitable for WB and reacts with Mouse, Rat samples. Cited in 1 publication.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR12169(B),
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Rat,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purity-Tissue culture supernatant, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
RD3 also known as retinol dehydrogenase 3 is a critical protein in visual processes. It possesses a molecular mass of approximately 25 kDa. RD3 is expressed mainly in retinal tissues where it plays an important role. The protein is necessary for proper phototransduction through its role in the retinoid cycle which is important for our visual perception.
Biological function summary
RD3 interacts with other proteins and retinoid intermediates to facilitate the efficient conversion of all-trans-retinol into 11-cis-retinal. This function supports the regeneration of visual pigments critical for light absorption. RD3 does not function as part of a larger complex; instead it works independently in its enzymatic role. Its activity ensures continuous visual cycle operation which is fundamental for maintaining normal vision.
Pathways
RD3 operates within the visual cycle known as the retinoid cycle. This cycle is essential for converting light into visual signals in the retina. RD3 is closely related to proteins like RDH5 in this cycle to maintain the necessary retinoid balance. RDH5 works alongside RD3 reflecting the intricate network of enzymes responsible for recycling visual pigments that detect light.
RD3's function is linked to retinal dystrophies. Mutations or dysfunctions in RD3 can lead to severe vision impairments such as Leber congenial amaurosis a hereditary retinal degenerative disorder. Furthermore RD3's relationship with RDH5 can influence the severity of visual impairment as both proteins are important for the retinoid cycle highlighting the importance of RD3 in maintaining ocular health.