Abcam, ab17221, Anti-TICAM2 antibody

Size: 100µg
Rabbit Polyclonal TICAM2 antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 4 publications. Immunogen corresponding to Synthetic Peptide within Human TICAM2.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IF, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human TICAM2. The exact immunogen used to generate this antibody is proprietary information.Q86XR7

Properties and Storage Information:
Form-Liquid, Purification technique-Ion exchange chromatography, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
TICAM2 also known as TRAM (TRIF-related adaptor molecule) plays an important role in the innate immune response by mediating signaling from Toll-like receptors (TLRs). It has a mass of approximately 27 kDa. TICAM2 is mainly expressed in immune cells such as macrophages and dendritic cells. It engages in complex interactions with TLRs specifically TLR4 to trigger downstream signaling cascades.
Biological function summary
The molecule participates in the modulation of immune responses. TICAM2 is a part of the MyD88-independent pathway interacting closely with TRIF (TIR-domain-containing adapter-inducing interferon-β) in signaling complexes. This interaction leads to the activation of transcription factors that stimulate the production of type I interferons and other cytokines critical for fighting viral infections.
Pathways
TICAM2 functions in the TLR signaling pathway bridging TLR4 and TRIF to regulate immune responses. It plays a significant role in the TRAM-TRIF pathway. This pathway is essential for activating NF-κB and IRF3 which lead to the expression of inflammatory genes. Proteins like TLR4 and TRIF are closely related to TICAM2 in these signaling pathways and contribute to immune regulation.
TICAM2 is associated with immune system-related conditions such as sepsis and autoimmune diseases. Its role in modulating inflammatory responses links it to these disorders. The interaction with TLR4 is significant as it implicates TICAM2 in the hyperactivation of inflammatory signaling pathways leading to excessive immune responses in sepsis. Similarly an overactive TICAM2-related pathway can contribute to autoimmune diseases by sustaining chronic inflammation.