Abcam, ab172367, Anti-LRRFIP2 antibody

Size: 50µg
Mouse Polyclonal LRRFIP2 antibody. Suitable for WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human LRRFIP2.
Key facts
Host species:Mouse,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Full Length Protein corresponding to Human LRRFIP2.Q9Y608

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
LRRFIP2 or Leucine Rich Repeat Flightless Interacting Protein 2 is a multifunctional protein weighing approximately 82 kDa. It interacts with actin and other cytoskeletal proteins and serves as a regulator of molecular interactions within the cell. LRRFIP2 localizes to the cytoplasm and is expressed in numerous tissues with a notable presence in immune cells. Its mechanical role primarily involves binding to specific nucleotides and transducing signals that subsequently influence cellular activities.
Biological function summary
LRRFIP2 plays a significant role in modulating immune responses and inflammation processes. It participates in forming a complex with Fliih GTPases and other signaling proteins to regulate signal transduction pathways. The protein acts as a mediator in the innate immune system facilitating the cellular response to pathogen-associated molecular patterns (PAMPs) and contributing to the activation of inflammatory pathways that initiate immune defense mechanisms.
Pathways
LRRFIP2 significantly impacts the Wnt/β-catenin and NF-κB pathways. Its interaction with proteins such as GSK3β and TLRs integrates LRRFIP2 into these key signaling cascades affecting gene expression related to cellular growth survival and inflammation. By influencing these pathways LRRFIP2 can alter the balance between pro-inflammatory and anti-inflammatory responses highlighting its role in maintaining cellular homeostasis and immune regulation.
Mutations or dysregulation of LRRFIP2 can associate with inflammatory and autoimmune diseases such as rheumatoid arthritis and Crohn's disease. Its interaction with other proteins like TNF-α and NOD2 links it to pathological conditions where chronic inflammation persists. These associations highlight the therapeutic potential of targeting LRRFIP2 in treatments aimed at reducing inflammation and managing autoimmune responses.