Abcam, ab172402, Anti-SACM1L/Sac1 antibody

Size: 100µg
Rabbit Polyclonal SACM1L/Sac1 antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human SACM1L.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IF, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Full Length Protein corresponding to Human SACM1L.Q9NTJ5

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
SACM1L also known as Sac1 is an integral enzyme in the cell performing its role as a phosphoinositide phosphatase. It has a mass of approximately 59 kDa. SACM1L localizes in the cytoplasm and the membrane systems of the endoplasmic reticulum and Golgi apparatus where it performs its enzymatic activities. Its expression is observed in many tissues with particular abundance in the brain and testis. The protein's ability to dephosphorylate phosphoinositides highlights its mechanical role in cellular lipid metabolism.
Biological function summary
This enzyme regulates intracellular lipid signaling and trafficking by modulating the levels of phosphoinositides. SACM1L is part of a protein complex involving other regulatory proteins that maintain the balance of lipid phosphates. Through its enzymatic activity SACM1L influences membrane dynamics and vesicular transport within cells. Taken together these activities show its importance in maintaining cellular homeostasis and function.
Pathways
SACM1L plays a role in phosphatidylinositol signaling and the vesicle-mediated transport pathway. Its action in these pathways involves interaction with proteins such as PIKfyve and Synaptojanin which are present in similar signaling events. SACM1L ensures the proper turnover of phosphatidylinositides which is critical for membrane identity and function in transport processes. These interactions highlight SACM1L's relevance to key signaling cascades within the cell.
SACM1L is implicated in neurodegenerative diseases and congenital disorders of glycosylation. Mutations or dysregulation in SACM1L have been linked to certain types of hereditary spastic paraplegia where it influences neuronal function and integrity. Additionally SACM1L's connection with proteins such as PGP and other phosphatases suggests its involvement in maintaining glycosylation patterns and cellular stress responses. Understanding its connection to these diseases could provide insights into novel therapeutic strategies.