Abcam, ab172474, Anti-CYP26A1 antibody [EPR11841]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal CYP26A1 antibody. Suitable for IHC-P, WB and reacts with Human samples. Cited in 3 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR11841,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purity-Tissue culture supernatant, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
CYP26A1 also known as Cytochrome P450 26A1 is a member of the cytochrome P450 superfamily responsible for the metabolism of endogenous and exogenous compounds. This enzyme weighs approximately 55 kDa. It plays an important role in the oxidative metabolism of retinoic acid a form of vitamin A. Predominantly it is expressed in the liver but expression is also seen in other tissues like brain and placenta. Monoclonal antibodies targeting CYP26A1 can facilitate research to better understand these expressions.
Biological function summary
CYP26A1 controls the levels of retinoic acid within cells by catalyzing its 4-hydroxylation ensuring precise regulation of cellular differentiation and proliferation. It is a part of the broader retinoid metabolism system which involves several other P450 enzymes that ensure the metabolic balance of retinoic acid. CYP26A1 works with these enzymes to tightly regulate this critical signaling molecule's presence impacting development processes.
Pathways
CYP26A1 significantly contributes to the retinol metabolism pathway and the broader retinoid signaling pathway. Its action helps manage the intricate balance of retinoic acid connecting it functionally to other cytochrome P450 enzymes like CYP26B1. These pathways play essential roles in modulating gene expression patterns during embryonic development and tissue differentiation.
CYP26A1's dysregulation relates to disorders such as congenital diaphragmatic hernia and certain cancers. Altered enzymatic activity affects retinoic acid levels leading to disrupted tissue differentiation and development. In some cancers proteins like retinoic acid receptor alpha (RARA) interact with dysregulated retinoic acid levels due to CYP26A1 anomalies influencing cancer progression and potential therapeutic targets.