Abcam, ab172908, Anti-FPR3 antibody [EPR11865]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal FPR3 antibody. Suitable for Flow Cyt, WB and reacts with Human samples. Cited in 2 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR11865,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, Flow CytSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purity-Tissue culture supernatant, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Formyl peptide receptor 3 (FPR3) also known as FMLP-R and FPRL2 is a G protein-coupled receptor with a molecular mass of approximately 39 kDa. FPR3 is positioned on the membrane of various immune cells including monocytes and neutrophils. This receptor plays an important role in detecting and responding to chemoattractant molecules. FPR3 can capture and transmit signals through conformational changes facilitating chemotaxis and other immune responses.
Biological function summary
FPR3 influences immune cell behavior and regulates the host's defense mechanisms. It participates in the chemotactic response directing immune cells to sites of infection or inflammation. While it is not part of a larger receptor complex FPR3 functions synergistically with other formyl peptide receptors like FPR1 and FPR2 to fine-tune immune responses. These coordinated activities help in controlling inflammation and microbial defense.
Pathways
Researchers have identified FPR3 as a significant component of the chemotaxis pathway in immune signaling. It interacts with key intracellular signaling molecules leading to the modulation of the MAPK signaling pathway. This coordination enhances immune cell mobility and function. FPR3 shares functional characteristics with related proteins such as FPR1 which also participates in the regulation of immune responses necessary for host defense.
FPR3 shows involvement in inflammatory conditions and certain types of cancer. Aberrations in FPR3 signaling may contribute to chronic inflammation impacting diseases like rheumatoid arthritis. Its dysregulation can affect cancer progression particularly in scenarios involving tumor-associated macrophages. The interactions between FPR3 and related immune proteins like FPR1 can influence the severity and prognosis of these conditions by modifying the immune environment in pathological tissues.