Abcam, ab172957, Anti-SELO antibody [EPR11968]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal SELO antibody. Suitable for WB and reacts with Human samples. Cited in 9 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR11968,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purity-Tissue culture supernatant, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
SELO also known as selenoprotein O is a protein that plays a role in cellular redox balance. The human SELO protein has a predicted mass of approximately 98 kDa. It is expressed in several tissues including the heart and skeletal muscle suggesting its importance in energy-demanding organs. The expression pattern indicates its involvement in stress response and maintenance of cellular homeostasis.
Biological function summary
SELO functions in redox homeostasis by modulating oxidative stress within cells. It participates in mitochondrial processes as it localizes predominantly within mitochondria. SELO is also a part of a protein complex where it interacts with thioredoxin and glutathione systems. This activity influences redox signaling and defends against damage to cellular components caused by excessive reactive oxygen species (ROS).
Pathways
The SELO protein plays a critical role in cellular antioxidant pathways. It interacts with the thioredoxin pathway an important element in maintaining the redox environment of the cell. SELO may have associations with proteins like thioredoxin reductase and peroxiredoxins which also operate within these antioxidant systems. This interaction helps regulate cellular responses to oxidative stress impacting overall cell survival and function.
SELO's involvement in oxidative stress management links it to conditions where oxidative damage is prevalent. Research highlights its potential role in neurodegenerative diseases such as Alzheimer's where oxidative stress contributes to neuronal damage. SELO can also intersect with proteins like tau and amyloid-beta which are important in Alzheimer’s pathology. Understanding SELO's role in these disease processes could open avenues for therapeutic interventions targeting oxidative stress.