Abcam, ab173292, Anti-LSM12 antibody [EPR12282-87]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal LSM12 antibody. Suitable for IHC-P, IP, WB, ICC/IF and reacts with Human, Mouse, Rat samples. Cited in 2 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR12282-87,
Isotype:IgG,
Carrier free:No,
Reacts with:Human, Rat, Mouse,
Applications:IHC-P, IP, ICC/IF, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
LSM12 also known as LSM12 homolog is a protein with a molecular weight of approximately 16 kDa. This protein is part of the Sm-like family known for their role in RNA processing. LSM12 is ubiquitously expressed in various tissues but shows higher presence in brain tissue indicating its potential importance in neurological functions. Its expression patterns suggest that LSM12 may have diverse roles across different cellular contexts.
Biological function summary
This protein is involved in cellular processes associated with mRNA decay and stability. LSM12 is a component of the LSM protein complex which plays an important role in RNA metabolism. The complex ensures accurate degradation and processing of mRNAn important steps required for maintaining cellular RNA homeostasis. Within the complex LSM12 interacts with other LSM proteins to promote efficient RNA handling and control.
Pathways
LSM12 is associated with RNA processing pathways including the nonsense-mediated decay (NMD) pathway. This pathway ensures the elimination of faulty mRNA transcripts which if left unchecked can disrupt cellular functions. In these pathways LSM12 may interact with UPF1 a well-known protein involved in NMD aiding in identifying and degrading erroneous mRNA molecules. This suggests that LSM12 supports the maintenance of genomic integrity through RNA surveillance mechanisms.
Researchers link LSM12 to neurodegenerative diseases like amyotrophic lateral sclerosis (ALS) and Alzheimer's disease. These connections highlight the significance of proper RNA metabolism in neuronal function. LSM12's interaction with other RNA processing proteins such as TDP-43 in ALS suggests a potential disruption of RNA stability as a contributing factor in these diseases. The study of LSM12 offers valuable insights into therapeutic targets for neurological conditions related to mRNA dysfunction.