Abcam, ab173296, Anti-Rap2A+Rap2B+Rap2C antibody [EPR12825(B)]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal RAP2A antibody. Suitable for IHC-P, WB, ICC/IF and reacts with Human samples. Cited in 2 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR12825(B),
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IF, IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Rap2A Rap2B and Rap2C are part of the Ras-related protein subfamily often called small GTPases. These proteins act as molecular switches that cycle between active GTP-bound and inactive GDP-bound states. The mass of these proteins is approximately 21 kilodaltons each. They are expressed in various tissues including the brain where they participate in signaling pathways critical for cellular communication. The three proteins share similarities in structure and function yet have unique roles in their specific cellular contexts.
Biological function summary
Rap2A Rap2B and Rap2C are involved in regulating cell migration adhesion and morphogenesis. As GTPases they interact with downstream effectors to modulate cytoskeletal dynamics and vesicle trafficking. These proteins are not part of a single complex but work collaboratively with various signaling proteins to transmit signals from the cell surface to the interior.
Pathways
Rap2 proteins play a role in the MAPK/ERK and PI3K/Akt signaling pathways. These pathways are important for cell growth survival and differentiation. They interact with proteins such as c-Raf and Akt transmitting external signals to influence cellular responses. Rap2 proteins contribute to the fine-tuning of these pathways affecting how cells respond to external stimuli.
Aberrant Rap2 signaling associates with cancer and neuronal disorders. Overexpression or mutations can lead to tumorigenic processes by affecting cell proliferation and survival mechanisms. Additionally their misregulation links to neurodegenerative conditions due to their role in neuronal signaling and plasticity. Other proteins like Ras and RhoA interact with Rap2 proteins in these pathological conditions indicating their importance in disease pathways.