Abcam, ab173298, Anti-AKAP associated Sperm Protein/ROPN1L antibody [EPR11266(B)]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal AKAP associated Sperm Protein/ROPN1L antibody. Suitable for IHC-P, IP, WB and reacts with Human samples. Cited in 1 publication.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR11266(B),
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, IHC-P, IPSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Species reactivity
Mouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species.
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contact us
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Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The AKAP-associated Sperm Protein also known as ROPN1L functions as a regulatory protein in spermatozoa. It has a molecular mass of approximately 24 kDa and exhibits expression in testicular tissue particularly in the sperm flagella. As a member of the A-kinase anchoring proteins (AKAPs) family it binds to protein kinase A (PKA) thereby localizing it to specific subcellular compartments. This localization is vital for the regulation of intracellular signaling pathways and is fundamental to the functions that the sperm must perform.
Biological function summary
AKAP-associated Sperm Protein plays an important role in sperm motility and structural integrity. It participates as part of a protein complex involving other proteins that modulate the actin cytoskeleton important for cellular movement and stability. Its interactions within this complex significantly affect the dynamics of cellular scaffolding where it helps maintain the proper organization and facilitates signal transduction linked to motility.
Pathways
AKAP-associated Sperm Protein integrates into signaling pathways that regulate cAMP levels. This protein links with the cyclic adenosine monophosphate (cAMP) signaling pathway which is important for the regulation of energy metabolism and neurotransmitter actions. Other proteins it interacts with include protein kinase A (PKA) and other signaling intermediates which together guide signal transduction impacting cellular responses and function particularly in reproductive processes.
AKAP-associated Sperm Protein connects to infertility issues and ciliary dyskinesia. Abnormal function of this target protein can lead to compromised sperm motility which is often linked to male fertility problems. In the case of ciliary dyskinesia the protein may interact with other related proteins like DYX1C1 leading to defects in ciliary movement. These dysfunctions underline the significance of proper AKAP-associated Sperm Protein activity within reproductive health.