Abcam, ab174267, Anti-HSPC111 antibody [EPR11971]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal HSPC111 antibody. Suitable for IP, WB, Flow Cyt (Intra) and reacts with Human samples. Cited in 1 publication.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR11971,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, IP, Flow Cyt (Intra)See reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies
Species reactivity
Rat: We have preliminary internal testing data to indicate this antibody may not react with this species.
Please
contact us
for more information.

Properties and Storage Information:
Form-Liquid, Purity-Tissue culture supernatant, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
HSPC111 also known as Nucleolar Protein 16 or NOL16 is a nucleolar protein with a molecular mass of approximately 111 kDa. It performs mechanical functions within the nucleolus and exhibits high expression levels in actively dividing cells like those found in embryonic tissues and malignant tumors. The protein's involvement in ribosomal biogenesis a critical cellular process contributes to its expression pattern. Researchers have observed HSPC111 overexpression in cancerous tissues indicating its importance in cell proliferation.
Biological function summary
HSPC111 contributes significantly to ribosomal RNA (rRNA) processing by forming part of the nucleolus. It interacts with multiple ribosomal biogenesis factors facilitating the synthesis and maturation of rRNA. As part of a larger ribonucleoprotein complex HSPC111 guides the processing and assembly of ribosomal subunits a step essential for efficient protein synthesis. This role showcases its integral nature in controlling translation rates within cells especially those requiring rapid protein production.
Pathways
HSPC111 plays an integral role in the ribosome biogenesis pathway where it collaborates with other nucleolar proteins like nucleophosmin (NPM1). The protein also forms connections within the p53 stress response pathway an interconnection that links ribosome production to cellular stress signals. Its activity impacts these pathways by regulating the availability of functional ribosomes which suggests its influence on cellular stress responses and apoptotic processes when dysfunction occurs.
HSPC111 exhibits notable associations with cancer and ribosomopathies. Elevated levels of HSPC111 are frequently found in various cancers suggesting its potential role as a biomarker or therapeutic target. It interacts with proteins like MYC a well-known oncogene driving unchecked cellular proliferation. In ribosomopathies abnormal HSPC111 activity contributes to improper ribosome production impacting protein synthesis and cellular growth therefore linking it to disorders where ribosome function is impaired.