Abcam, ab174276, Anti-TXNDC13/TMX4 antibody [EPR12321]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal TXNDC13/TMX4 antibody. Suitable for IP, WB, ICC/IF and reacts with Human samples. Cited in 1 publication.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR12321,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IF, WB, IPSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purity-Tissue culture supernatant, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
TXNDC13 also known as TMX4 is a protein involved in redox reactions functioning as a thioredoxin-like enzyme. This protein has a molecular mass of approximately 45 kDa and is located primarily in the endoplasmic reticulum. Expression of TXNDC13/TMX4 is observed in various tissues but it is notably high in ones where protein folding and secretion activities are extensive. The involvement of TXNDC13/TMX4 in protein disulfide isomerization centers around its ability to catalyze the formation and breaking of disulfide bonds in proteins which is essential for proper protein folding and maturation.
Biological function summary
The role of thioredoxin-like proteins such as TXNDC13/TMX4 is critical in maintaining cellular redox balance and participating in oxidative stress response. TXNDC13/TMX4 does not appear to be a part of a larger protein complex but operates by interacting directly with other proteins as a chaperone. It helps in the formation of disulfide bonds and alleviates misfolded proteins ensuring correct protein structure and function. This activity is particularly significant in cells with high secretory demands.
Pathways
TXNDC13/TMX4 is involved in pathways governing cellular redox homeostasis and the unfolded protein response. It acts in the thioredoxin pathway an important regulator of the cellular redox environment. The protein's functioning relates to other proteins such as PDI which are key elements in the protein-folding machinery within the endoplasmic reticulum. TXNDC13/TMX4 works closely with such proteins to manage oxidation and reduction reactions essential for controlling cellular oxidative stress levels.
TXNDC13/TMX4 links with conditions involving oxidative stress and protein misfolding such as neurodegenerative diseases and certain cancers. Dysregulation in this protein's activity can contribute to the aggregation of misfolded proteins exacerbating disorders like neurodegeneration. It may also have a role in tumor biology where altered redox states are often observed. The protein is connected to others like TXN which also influence cellular responses to oxidative stress further implicating it in the pathological mechanisms of these diseases.