Abcam, ab174294, Anti-WDTC1 antibody [EPR12504]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal WDTC1 antibody. Suitable for IHC-P, IP, WB, ICC/IF and reacts with Human samples. Cited in 2 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR12504,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IF, WB, IP, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
WDTC1 also known as Adipose is a protein that plays a role in various cellular processes. It is encoded by the WDTC1 gene and has a molecular weight of approximately 67 kDa. WDTC1 displays expression across many tissues with notable presence in adipose tissue and skeletal muscle. The protein contains WD40 repeats and a TBC (Tre-2/Bub2/Cdc16) domain which assist in protein-protein interactions and cellular trafficking.
Biological function summary
WDTC1 influences energy regulation and fat metabolism. It forms part of a protein complex that includes CUL4-DDB1 contributing to the ubiquitin-proteasome system. This activity regulates degradation of selective proteins ultimately controlling fat storage and mobilization. WDTC1 affects adipogenesis by modulating transcription factors and is involved in lipid metabolism through interactions with other cellular proteins.
Pathways
WDTC1 is actively involved in the regulation of metabolic pathways. It engages with the insulin signaling pathway and the PPARγ (peroxisome proliferator-activated receptor gamma) pathway both essential for energy homeostasis and fat cell differentiation. WDTC1 interacts with insulin receptor substrate proteins and partners with other ligase components to mediate the effects of these pathways on metabolism.
WDTC1 connects to obesity and type 2 diabetes. Variations in WDTC1 expression and function can disrupt normal fat metabolism contributing to these metabolic disorders. It associates with the hormone leptin a critical player in maintaining body weight linking WDTC1 to adipose tissue dysfunction. Understanding the role of WDTC1 may offer insight into therapeutic targets for metabolic disease management.