Abcam, ab174459, Recombinant Human CUEDC1 protein

Size: 50µg
Recombinant Human CUEDC1 protein is a Human Full Length protein, in the 1 to 386 aa range, expressed in Escherichia coli, with >85%, suitable for SDS-PAGE, Mass Spec.
Key facts
Purity:>85% SDS-PAGE,
Expression system:Escherichia coli,
Tags:His tag N-Terminus,
Applications:Mass Spec, SDS-PAGESee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Biologically active:No,
Accession:Q9NWM3,
Animal free:No,
Carrier free:No,
Species:Human,
Storage buffer:pH: 8Constituents: 20% Glycerol (glycerin, glycerine), 0.88% Sodium chloride, 0.32% Tris HCl, 0.02% (R*,R*)-1,4-Dimercaptobutan-2,3-diol

Properties and Storage Information:
Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
CUEDC1 also known as CUE domain-containing protein 1 is a protein with a mass of approximately 42 kDa. Mechanically CUEDC1 contains a CUE domain which is known to interact with ubiquitin. This domain enables CUEDC1 to play a significant role in protein-protein interactions. CUEDC1 is expressed in various human tissues including the brain liver and heart. Its expression pattern suggests its involvement in a broad range of physiological processes.
Biological function summary
The function of CUE domain-containing protein 1 revolves around its potential role in cellular signaling and regulation. It forms part of a complex that regulates protein degradation processes through the ubiquitin-proteasome system. This involvement suggests that CUEDC1 affects the stability of specific proteins within the cell influencing various cellular outcomes such as cell cycle and apoptosis.
Pathways
CUEDC1 functions within the ubiquitin-mediated proteolysis pathway influencing protein turnover and cellular homeostasis. It associates with proteins like ubiquitin ligases that modify proteins with ubiquitin tagging them for degradation. Additionally CUEDC1 interacts with components of the ERK/MAPK signaling pathway impacting cell proliferation and differentiation.
CUEDC1 links to cancer and neurodegenerative diseases. Altered expression levels of CUEDC1 have been observed in certain cancers suggesting it may influence tumor progression. Additionally disruptions in its function might contribute to neurodegenerative conditions possibly through its role in the degradation of misfolded proteins connecting to proteins like tau known to aggregate in Alzheimer's disease.