Abcam, ab174699, Anti-EMP2 antibody - C-terminal

Size: 200µL
Rabbit Polyclonal EMP2 antibody. C-terminal. Suitable for WB, IHC-P and reacts with Mouse, Human samples. Cited in 4 publications. Immunogen corresponding to Synthetic Peptide within Human EMP2 aa 50-150 conjugated to Keyhole Limpet Haemocyanin.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Human,
Applications:WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human EMP2 aa 50-150 conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information.P54851

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.4Preservative: 0.09% Sodium azideConstituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The protein epithelial membrane protein 2 (EMP2) also known as EMP2 or emp002 has a mass of approximately 20 kDa. EMP2 is expressed mainly in epithelial cells and certain tissues including the lungs breast and reproductive tissues. It appears on the cell surface where it modulates several cell processes. EMP2 plays a role in cell surface configuration by influencing the localization of other critical membrane proteins.
Biological function summary
EMP2 influences the cell's ability to undergo endocytosis a process important for nutrient uptake and signal transduction. It is part of a multiprotein complex that interacts with integrin and caveolin which are essential for cellular adhesion and signaling. EMP2 impacts cellular communication and growth emphasizing its role in maintaining cellular homeostasis.
Pathways
EMP2 is involved in the integrin-mediated pathway and the caveolae-mediated endocytosis pathway. It impacts integrin beta-1 (ITGB1) and c-Src kinase which are proteins important in cell signaling and mobility. These pathways facilitate various cellular functions including signal transmission and regulation of the cytoskeleton. EMP2's interaction with these pathways underlines its significance in cellular processes.
EMP2 has connections to lung cancer and endometriosis. Its altered expression influences disease progression and is associated with metastatic potential. EMP2 acts in concert with proteins such as β-catenin and fibronectin which contribute to cancer development and cellular invasiveness. Understanding EMP2's role offers insights into potential therapeutic targets for these conditions.