Abcam, ab174829, Anti-NDUFA10 antibody [EPR12135]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal NDUFA10 antibody. Suitable for IHC-P, IP, WB, ICC/IF and reacts with Human samples. Cited in 4 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR12135,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, IHC-P, ICC/IF, IPSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Species reactivity
Mouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species.
Please
contact us
for more information.
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purity-Tissue culture supernatant, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
NDUFA10 also known as NDUFA10 subunit of NADH:Ubiquinone Oxidoreductase is a component of the mitochondrial respiratory chain. It has a molecular mass of approximately 42 kDa. This protein is ubiquitously expressed throughout human tissues and it plays an important role in the electron transport chain as part of Complex I. NDUFA10 is important for the assembly and stability of Complex I influencing the proper functioning of the oxidative phosphorylation system.
Biological function summary
This protein aids in the enzymatic activity necessary for mitochondrial electron transfer. NDUFA10 serves as a subunit within Complex I of the mitochondrial membrane. Complex I acts as the first enzyme of the electron transport chain promoting the transfer of electrons from NADH to ubiquinone. This step is essential for energy production through ATP synthesis. As part of this complex it contributes to maintaining cellular respiration and energy homeostasis.
Pathways
Complex I plays an important role within the oxidative phosphorylation pathway and the tricarboxylic acid (TCA) cycle. These pathways are foundational for cellular metabolism and ATP production. NDUFA10 interacts with other Complex I subunits such as NDUFS1 and NDUFA5 ensuring efficient electron flow and energy conversion. Disruptions in this pathway could lead to alterations in energy metabolism impacting cellular function and health.
Research associates NDUFA10 with mitochondrial disorders and neurodegenerative diseases. Altered NDUFA10 function can impact Complex I activity leading to mitochondrial dysfunction. Such dysfunction often correlates with conditions like Leigh syndrome and Parkinson's disease. NDUFA10 interacts with other proteins involved in these disorders including those within the electron transport chain like NDUFB8 and NDUFS8 highlighting its involvement in maintaining mitochondrial health and energy balance.