Abcam, ab175207, Anti-MRPS17 antibody [EPR12583]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal MRPS17 antibody. Suitable for IHC-P, IP, WB, ICC/IF and reacts with Human samples. Cited in 3 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR12583,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, IHC-P, IP, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Species reactivity
Mouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species.
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contact us
for more information.
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purity-Tissue culture supernatant, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
MRPS17 also known as mitochondrial ribosomal protein S17 is a component of the mitochondrial ribosome small subunit. It weighs approximately 17 kDa. MRPS17 expresses in tissues throughout the body especially in those with high-energy requirements like muscle and brain. MRPS17 is essential for mitochondrial protein synthesis where it contributes to translating mitochondrial-encoded messages into functional proteins.
Biological function summary
The protein MRPS17 acts as part of the mitochondrial ribosome which contains many different proteins and ribosomal RNA. This complex plays a significant role in cellular energy metabolism by producing proteins essential for the electron transport chain. MRPS17 ensures that mitochondria maintain their capacity to synthesize proteins that drive ATP production. Without this process cells would lack adequate energy supply.
Pathways
MRPS17 engages in critical roles within mitochondrial translation pathway and oxidative phosphorylation pathway. These pathways facilitate the proper function of mitochondria in energy production. MRPS17 interacts with other mitochondrial ribosomal proteins like MRPS18 ensuring the accuracy and efficiency of protein synthesis. This interaction supports overall mitochondrial and cellular health.
Defects in MRPS17 relate to mitochondrial diseases such as Leigh syndrome and mitochondrial cardiomyopathy. These conditions often arise from disrupted energy production in cells. Genetic mutations affecting MRPS17 might impair mitochondrial function leading to clinical symptoms. MRPS17 shares connections with other mitochondrial proteins like MRPS16 in the context of these disorders highlighting its relevance in related pathological states.