Abcam, ab175221, Anti-ATRIP antibody [EPR8072(2)]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal ATRIP antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 4 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR8072(2),
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purity-Tissue culture supernatant, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
ATRIP also known as ATRIP protein serves as an essential component within the ATR-ATRIP complex which is vital in the DNA damage response. ATRIP is a protein that weighs approximately 86 kDa and is most commonly expressed in the nucleus of cells. It functions primarily by binding to ATR (Ataxia Telangiectasia and Rad3-related protein) which enables the ATR to localize to sites of DNA damage and replication stress. This enables the recognition and repair of damaged DNA preventing genomic instability.
Biological function summary
ATRIP plays roles in maintaining genome integrity. It forms a stable complex with ATR which is important for the activation of ATR kinase activity. ATRIP directly interacts with single-stranded DNA coated by replication protein A (RPA) to perform its functions. By facilitating ATR recruitment to DNA damage sites ATRIP aids in the initiation of DNA repair mechanisms which are critical for normal cellular function and survival.
Pathways
ATRIP's activities are an integral part of the DNA damage signaling and repair pathways. ATR-ATRIP complex is central to the DNA replication checkpoint pathway where it maintains replication fork stability and controls cell cycle progression. Additionally ATRIP is involved in pathways alongside proteins like CHK1 which it helps to activate in response to DNA damage ensuring proper cell cycle arrest and repair processes.
ATRIP is implicated in certain cancers and genomic instability syndromes. Deficient ATRIP function can correlate with a higher predisposition to cancers due to defective DNA damage response and repair. Further the ATR-ATRIP interaction can influence the onset and progression of Seckel syndrome where defects in ATRIP or its partner ATR might lead to developmental abnormalities. The role of ATRIP in these diseases highlights the importance of maintaining genomic stability through effective DNA repair mechanisms.