Abcam, ab175222, Anti-ITPK1 antibody [EPR10631]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal ITPK1 antibody. Suitable for IHC-P, IP, WB, Flow Cyt (Intra) and reacts with Human samples. Cited in 2 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR10631,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, Flow Cyt (Intra), IP, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Species reactivity
Mouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species.
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contact us
for more information.
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The enzyme inositol 134-trisphosphate 5/6-kinase commonly known as ITPK1 catalyzes the phosphorylation of inositol trisphosphate (IP3) to produce higher phosphorylated forms of inositol phosphates. ITPK1 has a molecular mass of approximately 47 kDa and expresses in various human tissues though it is highly expressed in the brain and skeletal muscles. Researchers often measure ITPK1 activity using inositol trisphosphate (IP3) assays including IP3 ELISA and IP3 measurement methods.
Biological function summary
ITPK1 is involved in regulating cellular levels of inositol phosphates acting as a significant node in the inositol signaling pathways. As a part of a kinase complex it modulates cellular processes like signal transduction osmoregulation and cell growth. ITPK1's role in controlling IP3 levels positions it as a contributor to maintaining cellular homeostasis and enabling proper cellular responses to external stimuli.
Pathways
ITPK1 plays an essential role in the IP3 pathway by converting inositol trisphosphate (IP3) into inositol tetrakisphosphate (IP4). This pathway influences calcium release within cells impacting various physiological processes. ITPK1 is associated with pivotal signaling proteins like IP3 receptors which bind with IP3 to trigger intracellular calcium release playing an important role in cellular signaling and communication networks.
Mutations or dysfunctions in ITPK1 have links to conditions like schizophrenia and Down syndrome. Schizophrenia may relate to altered inositol phosphate metabolism wherein interactions with proteins like IP3 receptors are disrupted. ITPK1 also shows a connection to Alzheimer's disease due to its role in calcium signaling pathways which influences neuronal function and survival. These associations highlight ITPK1's potential significance in neuropsychiatric and neurodegenerative diseases.