Abcam, ab175928, Anti-EPB41L2 antibody [EPR8873(2)]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal EPB41L2 antibody. Suitable for IHC-P, IP, WB, ICC/IF and reacts with Human, Rat samples. Cited in 2 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR8873(2),
Isotype:IgG,
Carrier free:No,
Reacts with:Rat, Human,
Applications:IHC-P, WB, ICC/IF, IPSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
EPB41L2 also known as erythrocyte membrane protein band 4.1-like 2 has a mechanical role in stabilizing cell membranes by linking the cytoskeleton to the plasma membrane. This protein weighs approximately 90 kDa. EPB41L2 is widely expressed in various tissues with a notable presence in the brain and nervous system where it impacts neuronal structure and signal transmission. The structural integrity that EPB41L2 provides to cellular membranes aids in maintaining cellular shape and signal transduction.
Biological function summary
EPB41L2 is a critical component of the 4.1 protein family which regulates cytoskeletal architecture and cellular adhesion. This protein interacts with spectrin and actin playing a role in the formation and stability of the spectrin-actin network. Within cells EPB41L2 associates with lipid rafts which are small dynamic cholesterol-enriched domains in the membrane facilitating signal transduction and protein sorting. This positioning suggests its involvement in complex cellular processes requiring membrane organizing capabilities.
Pathways
EPB41L2 plays essential roles in the pathways regulating cytoskeleton rearrangement and cell adhesion. It is particularly implicated in the Rho GTPase signaling pathway where it interacts with proteins such as RhoA influencing cytoskeletal dynamics and cell motility. Additionally EPB41L2 is part of the regulation pathway of cell shape and polarity particularly in neurons affecting interactions with proteins involved in axonal guidance and synaptic function.
EPB41L2 has associations with conditions affecting the nervous system such as neurodevelopmental disorders and certain types of epilepsy. EPB41L2's dysregulation may contribute to altered neuronal connectivity and signal transmission exacerbating these conditions. Additionally EPB41L2 interactions with ankyrin or neurofascin could be disturbed in pathological states leading to instability in neural structures and potentially contributing to disease progression.